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By acting as a direct signaling molecule from the mitochondria, it targets the fundamental cellular processes that govern energy balance and resilience
1994, 266: R979-R988
In vitro, the HER2xAPLP2 BsADC with a DAR of 4 exhibited potent cytotoxicity against HER2-positive cells (e.g., IC 50 of 0.8 nM in BT-474), significantly outperforming a conventional HER2-targeting ADC
In laboratory settings, AOD-9604 has been studied for its interactions with beta-3 adrenergic receptors, which play a role in adipocyte metabolism
These findings implicate CHAC2 in various cellular functions, including DNA replication and repair, cell cycle regulation, apoptosis, and stem cell differentiation, indicating that its functional repertoire is more versatile than initially presumed (Peng et al., 2023
