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Results from a 2-year randomised controlled trial (CIMESTRA)
Comparisons of within-subject changes between baseline and follow-up were evaluated with unadjusted paired t -tests and Wilcoxon signed-rank test for continuous outcomes, and McNemars test for categorical outcomes
Extension phases and trials enrolling exclusively individuals without diabetes were excluded
Respect all directions regarding medication, fasting, and observation for the safest outcome
GLP-1 medicines act on hormone pathways involved in appetite, fullness, food intake and glucose regulation
It has been demonstrated that oxidative stress-mediated GSH depletion is crucial in controlling transient outward K+ currents in rat ventricular myocytes, which may be the cause of diabetes-related decreased contractility and aberrant electrical characteristics
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