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Differences in assay methods preclude meaningful comparisons of the incidence of anti-drug antibodies in the studies described below with the incidence of anti-drug antibodies in other studies, including those of semaglutide or of other semaglutide products

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The dose of plasmid for both LNP and HD was 0.5 g g 1 , with injection volumes of 10 l g 1 for LNP and 100 l g 1 for HD

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The Big Trial of a GLP-1 drug (Wegovy) to Reduce Major Cardiovascular Events Presented at the American Heart Association and simultaneously published in NEJM today is the trial of over 17,600 patients who were randomly assigned either the GLP-1 semaglutide (a glucagon-like peptide-1 receptor agonist) or placebo and were followed for well over 3 years