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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
For this reason, its even more important as we age to talk to a doctor about whether or not our bodies are absorbing the vitamins we need
However, there is a low risk of vitamin B12 toxicity because the body only utilizes what it needs and eliminates the excess
PMID 35337622
This article explains why a person with Crohns disease may have a vitamin B12 deficiency and how doctors may diagnose it
As one expert says, Regular monitoring is essential to tailor Vitamin B12 therapy to individual patient needs and prevent over- or under-treatment. Response-Based Dosing Strategies We adjust Vitamin B12 doses based on how well the patient responds
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