Tirzepatide (Mounjaro/Zepbound) may cause slightly more GI side effects overall because it targets two receptors (GLP-1 + GIP), but individual responses vary
This is particularly important for individuals with pre-existing health conditions including liver disease, conditions affecting copper metabolism (such as Wilson's disease), cardiovascular disease, or gastrointestinal disorders those taking prescribed medications, or those who are pregnant, breastfeeding, or planning a pregnancy
Naveed Azhar , a leading fitness professional, explains that Ozempic works best when paired with healthy eating and regular activity
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However, because some estimates were imprecise, particularly for rarer outcomes of major congenital malformation and small birth size, the authors said further research would be valuable to better understand the safety of GLP-1s in pregnancy