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This is reinforced by the decreased levels of glutamate and pyroglutamate, products of glutamine metabolism [53], in most GLS1 knockdown conditions and models
However, MT-1's lower dosing frequency (2x/week vs daily during loading) partially offsets this
GI overlap
Keep in mind that benzoyl alcohol present in the formulation can cause tenderness at the site of injection
On the other hand, lingering concerns about pancreatic malignancy risk with GLP-1 therapy created hesitation, especially in patients with prior pancreatitis or a strong family history of pancreatic cancer
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