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The major source of ROS comes from non-enzymatic processes in the mitochondrial respiratory chain ( Everything has two sides, and it is crucial for cell to regulate ROS levels to avoid oxidative stress

Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

Early evidence points to real benefits, though theres still a lot to uncover

Mitchell RM, Freeman WM, Randazzo WT, Stephens HE, Beard JL, Simmons Z, et al

BioMed Research International, 2015 , 648108

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