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These higher plasma levels of -endorphin may serve to the pathogenesis, as -endorphins in the CNS have insufficient inhibition on GnRH [151, 153]
He also points to medication discontinuation as a reason to continue monitoring OSA over time
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The SELECT Trial: Inflammation and Cardiovascular Outcomes The landmark SELECT trial which demonstrated a 20% reduction in cardiovascular events with semaglutide in people without diabetes provides perhaps the most compelling evidence linking semaglutides anti-inflammatory effects to real clinical outcomes
For instance, Wegovy injections, which contain a higher dose of semaglutide than Ozempic, are specifically FDA-approved for chronic weight management in adults and adolescents with obesity or overweight with at least one weight-related condition [7] [8]
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