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(3) Fan Ye, Sunita Mathur, Min Liu, Stephen E Borst, et al (2016) Overexpression of IGF-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse Experimental Physiology, 2013 Jan 4, Volume 98 (Issue 5), Pages 10381052

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The conversion of homocysteine to cystathionine requires pyridoxal phosphate (PLP)

Such mutations impair cellular uptake of riboflavin, leading to reduced FMN and FAD synthesis and consequent dysfunction of mitochondrial FAD-dependent enzymes, culminating in axonal degeneration, motor neuron disease, and sensory neuropathy