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This proteolysis, primarily mediated by the ubiquitinproteasome pathway, leads to a net negative nitrogen balance and significant loss of lean body mass, a major contributor to poor outcomes and long-term physical impairment 44
Systemic injection into abdominal fat also provides benefits, though potentially less concentrated at the specific injury site
The compound enhances cytotoxic T lymphocyte responses and prevents immunological unresponsiveness
Additionally, BPC-157 interacts with the dopaminergic and serotonergic systems, which may explain its observed neuroprotective properties in preclinical models of traumatic brain injury and nerve damage
Cell 187 , 23242335.e2319 (2024)
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