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Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes

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It is postulated that GLP-1 RAs activate the GLP-1 R and transactivate the epidermal growth factor receptor (EGFR) via metalloproteinases

Patients should receive comprehensive education regarding signs and symptoms that could indicate malignancy and should be counseled to report any new symptoms or changes promptly