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Subsequent clinical double-blind controlled trials indicated that multi-dose flavonoid regimens (200800 mg daily) were safe, well-tolerated, and without significant accumulation, supporting the potential of flavonoid-based supplements in PD management (Pang et al., 2016)
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Any discomfort is easily treated with over-the-counter pain medication, allowing patients to jump back into their activities without hesitation
It induces a restful sleep that energizes the body
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Informal protocols generally avoid doubling the next amount because safety and dose limits are unknown
