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Biochem Soc Symp 1978;43:16382
Forkhead box protein O4 (FOXO4) is an anti-apoptotic transcription factor which is upregulated in some senescent cells and prevents cell death by sequestering the nuclear protein p53 (70)
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CagriSema has a very nice efficacy in that regard in type 2 diabetes
Unfortunately, there are two key issues which make this unreliable: If the patient has been taking folic acid, this will normalise the blood cell appearance and create a false negative
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