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Therefore, activating variants in the CaSR lead to excessive inhibition of K + efflux resulting in intracellular Cl accumulation
While the study found no significant differences in the primary efficacy endpoint (time to first tolerated meal), the ipamorelin group showed reduced median time to first tolerated meal (25.3 hours versus 32.6 hours in placebo) and had fewer overall treatment-emergent adverse events (87.5% versus 94.8%)
These studies suggest potential BPC-157 benefits for digestive as well as joint and muscle integrity and functionality, laying the groundwork for further research in humans
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