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Since its discovery in the 1950s, the antimetabolite 5FU has been the cornerstone of fluoropyrimidine-based chemotherapy treatment for patients with CRC

These functions make it essential for maintaining overall health and combating the effects of aging, stress, and environmental toxins

These findings support the hypothesis that weight loss is largely exposure-driven and may be comparable across agents at specific dose levels

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The quality of each tissue was evaluated using H&E-stained sections and PPIB and Polr2a/PPIB ISH stains