They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology
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Deficiency leads to methylmalonic acid accumulation, which may incorporate abnormal fatty acids into myelin, further compromising nerve function
Researchers also found that decreasing NNMT caused a 47% reduction in the mices fat mass
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