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Isoureguanidine alkaloids target the miR-122-5p/TP53/SLC7A11 axis, upregulating miR-122-5p and SLC7A11 while suppressing TP53 to prevent ferroptosis (215)
The types of drugs involved include synthetic peptides, small molecule drugs, recombinant peptides and fusion proteins, etc
[10] [11] The mechanism by which these medications reduce appetite involves both peripheral and central pathways
47 : 3945 Davis S, Markowska AL, Wenk GL, Barnes CA
It also modified circulating endothelial cells, vascular endothelial growth factor (VEGF)-A concentrations, and decreased IGF-1R phosphorylation
Inconsistent semaglutide dosing can compromise both treatment efficacy and safety
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