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The hypothesis is that there are two pathway mechanisms for the protective cardiovascular action of GLP-1

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Based on previous randomized studies evaluating the effects of GLP-1 receptor agonists on smoking-related outcomes and nicotine dependence, the standard deviation of FTND scores was estimated to be approximately 2 points, and a 2-point reduction was considered clinically meaningful ( Blinding and randomization After obtaining informed consent and completing baseline assessments, participants will be randomly assigned in a 1:1 ratio to the GLP-1RA group or the control group