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Lawrence BJ, Jayakody DMP, Bennett RJ, Eikelboom RH, Gasson N, Friedland PL

Except every time I waited too long, the next time I did try to eat, my stomach acted like I was punishing it

Genetic variants in B12 metabolism pathways (e.g., MTHFR, MTR, MTRR genes) can influence how efficiently your body processes and utilizes B12, potentially affecting both side-effect risk and clinical benefit

Procedures such as sleeve gastrectomy and Roux-en-Y gastric bypass produce average weight reductions of 25 to 35% and remain the most durable interventions available for severe obesity and obesity-related metabolic disease

Even when appetite is significantly reduced, it is important to maintain adequate intake of: Protein (to preserve lean muscle mass and support energy) Complex carbohydrates (to sustain blood glucose levels) Iron, B12, and folate (to help prevent nutritional anaemia if deficiency is suspected, speak to a GP for testing before starting supplements) Fluids aim for around 68 drinks per day (approximately 1.21.5 litres), in line with NHS hydration guidance

For Wegovy, if you miss two or more consecutive doses , the FDA labeling recommends considering re-escalation of the dose