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At 25C (room temperature), dissolved GSH in aqueous solution oxidizes at a rate of approximately 25% per week
For example, in patients with metastatic breast cancer, TOPI mutations have emerged as a mechanism of acquired resistance after treatment TOPI inhibitor-based ADCs, conferring resistance to a second ADC with a similar TOPI inhibitor payload 39
MR-PRESSO detected outliers in the overall associations with CAD in FinnGen (shown in Additional file 1: Table S5), where we used corrected estimates from MR-PRESSO
Marrero JA, Fontana RJ, Fu S, Conjeevaram HS, Su GL, Lok AS
Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment
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