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This isn't just about 'feeling' tired
In addition, the nanovaccine Si9GM is made of central radial mesoporous silica nanoparticles coated with membranes from bone marrow-derived dendritic cells (BMDCs) expressing antigen peptides, used to deliver CLEC9A-antigen conjugates and STING agonists (23-cGAMP), which can selectively target cDC1, promote DCs maturation, and lead to upregulation of cytotoxic T cells, reduction of Tregs, and M1/M2 macrophage polarization and can induce strong tumor growth and metastasis inhibition when combined with PD-1 blockade (224)
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doi: 10.2337/db25-0282 202 HuangDShenPWangCGaoJYeCWuF
"Every morning I wake up and think " oh good, I get an ALOHA Bar
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