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This triple-agonist mechanism is what makes it potentially more effective than single-agonist peptides like semaglutide , but it also means the gastrointestinal side effects can be more intense if you start too high
The principal mechanism of protraction resulting in the long half-life of semaglutide is albumin binding, which results in decreased renal clearance and protection from metabolic degradation
Worked perfectly
Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe
However, advancements in supplement manufacturing have changed this landscape
2010 Feb 25;160(1-3):26-32
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