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Clinical trial averages: Wegovy (semaglutide): ~15% of body weight Zepbound (tirzepatide): ~20% of body weight Some people lose considerably more

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The ability of GLP-1 agonists to diminish appetite has made them popular with celebrities and social media fitness influencers

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Their findings showed: Osteoporosis: About 4% of GLP-1 users developed osteoporosis, compared with just over 3% of non-users Osteomalacia (softening of the bones): Occurred nearly twice as often among GLP-1 users Gout: Occurred in 7.4% of GLP-1 users vs

Extrapolation from one study population to another has limits