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J Invest Dermatol 130:27819 Shen G, Xu C, Hu R (2006) Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

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In parallel, it alters transcriptional pathways involved in angiogenesis, cytokine production, and tissue remodeling, including PI3K/Akt and NF-B cascades

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1 Based on published clinical studies evaluating menopausal hormone therapy and symptom reduction outcomes

Nussbaum RL, Ellis CE