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Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo

Tao YX, Conn PM

Mucosal extracts for quantification of GLP-1 Frozen lean or HFD obese rat gastric mucosal scrapings and human fundic and antral biopsies were homogenized (TissueLyser II, Retsch France) with an ice-cold buffer containing 1.5% HCl 1 M and 75% ethanol

Therefore, carnitine pool not only affects liver metabolism, but also affects the communication and metabolic cooperation between the liver and multiple organs

Lets unpack what they might suggest