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[1] Investigational status: large-scale human trials still needed

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Studies have shown that 1-AR antagonists, such as doxazosin, alleviate liver sinusoid capillarization and hepatic angiogenesis by inhibiting the expression of vascular endothelial cell markers (such as CD31 and vWF), thereby alleviating liver fibrosis 18

Ser-65 forms a hydrogen bond with the GSH -glutamyl carboxylate [80, 83]