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Cruz-Jentoft AJ, Sayer AA
The FDA does not review compounded medications for safety, effectiveness, or quality before marketing
When applied topically, taken orally or injected, peptides can penetrate the skins surface and target specific areas needing repair or improvement
A 2018 review by Sikiric et al
These regions are believed to be involved in many of the non-enzymatic functions of DPP-4, interacting with other proteins, such as adenosine deaminase, caveolin-1, streptokinase and plasminogen, and with components of the extracellular matrix (collagen, fibronectin), as well as functioning as binding sites for the chemokine CXCR4 receptor, the T-cell differentiation antigen, CD45, and the sodium-hydrogen exchanger-3, among others ( Table 1 The proline-specific peptidases