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Abbreviations ALK: Anaplastic lymphoma kinase ALL: Acute lymphoblastic leukemia EGF: Epidermal growth factor ER: Estrogen receptor FAK: Focal adhesion kinase FGF: Fibroblast growth factor HGF: Hepatocyte growth factor HNSCC: Head and neck squamous carcinoma IGF: Insulin-like growth factor IGFBP: IGF-binding protein IGF-IR: Type I insulin-like growth factor receptor IGF-IIR: Type II IGF receptor InsR: Insulin receptor mAbs: Monoclonal antibodies MAPK: Mitogen-activated protein kinase PDGF: Platelet-derived growth factor PI3K: Phosphatidylinositol 3-kinase RTK: Receptor tyrosine kinase TGF: Transforming growth factor VEGF: Vascular endothelial growth factor References Bach LA

The first sign of degradation is a color shift from clear pale blue to greenish-brown, followed by haze or visible particulate

The primary mode of action for these bacteriocins involves either pore formation in the target cell membrane or inhibition of cell wall synthesis, ultimately resulting in bacterial cell death (196, 197)