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Mechanism studied: NNMT catalyses the methylation of nicotinamide

For people with a B12 deficiency, injections are often prescribed because they allow for better absorption than oral supplements

Researchers continue to investigate how NNMT inhibition may alter cellular metabolic processes and affect broader physiological systems involved in metabolic health

5-Amino-1MQ may inhibit NNMT activity with possible effects on NAD+ and S-adenosylmethionine (SAM) dynamics in experimental models

Because the vitamin deposits into muscle rather than entering the vasculature immediately, intramuscular delivery produces a sustained release effect

Damage can occur from many sources, including: Diabetes A leading cause of neuropathy Infections Such as Lyme disease or shingles Auto-immune diseases Conditions like lupus and rheumatoid arthritis can attack the peripheral nerves Chemotherapy Some cancer treatments can cause nerve damage Nutritional deficiencies namely Vitamin B12 So now we know a little more about neuropathy and its causes lets move on to B12