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What sets Retatrutide apart is its unique ability to engage three receptors simultaneously: GIP (Gastric Inhibitory Polypeptide) receptor GLP-1 (Glucagon-Like Peptide-1) receptor GCG (Glucagon) receptor This puts Retatrutide into a new medication class known as triple agonists

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This explains why GLP-1s were selected first to treat diabetes

The requirement for informed consent was waived by the special ethics committee of the Kanagawa Medical Association, Japan, owing to the retrospective and observational nature of the study

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