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This dark color can be associated with significant kidney dysfunction where waste products like bilirubin and myoglobin are present in higher concentrations
doi: 10.3389/fendo.2022.1099451 16 MenzenMBerentzenTLCatarigAMPieperhoffSSimonJJacobS
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In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes
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