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If you or someone you know uses GLP-1s, you might worry about a problem called bowel obstruction
W., Morris, J
Moreover, due to these substitutions, semaglutide has a prolonged half-life of approximately 168 h, which is impressive given the knowledge that native GLP-1 has a half-life of 2 min, in comparison [98, 99]
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However, when paired with potent GLP-1 and GIP agonism, the glucose-raising effect of glucagon is overridden by the insulinotropic effects of the other two pathways