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MTTP gene transcription is positively regulated by PPAR and increased MTTP expression is paralleled by a change in apoB100 secretion, but a paradoxical decrease in circulating triglycerides in mice [116]
A guide to analysis of mouse energy metabolism
C.PapageorgiouI.PapadopoulouP.TerzioglouE.ChrousosG
The review also concludes that although early studies are promising, most have involved small groups of patients, different study designs, and short follow-up periods