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Based on the strength of evidence and safety boundaries, a more rational clinical positioning is to reserve GLP-1RAs as an individualized tool for intensive metabolic optimization prior to ART in refractory PCOS individuals with high BMI and prior weight-loss failure
Furthermore, the World Health Organization has identified obesity as a global epidemic, which underscores the urgent need for innovative solutions within the market
Chemotherapy can also impact fertility, sexual health, and bone strength, which is why many clinics now offer fertility counseling and bone health checks before and after treatment
Pharmacologically, GLP-1R is a G-protein coupled receptor (GPCR) critical for glucose homeostasis, which mediates the effects of GLP-1R agonists [26, 27]
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