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Side effects may also limit the usefulness of these agents: nearly 20% of those with IBS-C and 16% of those with chronic constipation treated with linaclotide developed diarrhea, both significantly higher rates than in the placebo groups

Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants

Commitment to Lifestyle Changes : GLP-1 medications are most effective when paired with healthy habits

doi:10.1016/j.beem.2013.08.005

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We are thus left with poorly studied experimental drugs referred to as peptides, although some are not, sold for research use only, though clearly meant for human consumption, to gain a wide array of physical benefits that are unlikely to manifest