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GLP-1 receptor agonists like semaglutide have multiple favorable effects on both metabolism and inflammation

Heartburn and reflux symptoms appear to occur in a subset of patients, though exact prevalence rates vary depending on the trial population and reporting methods

Genome Biology 15, R27

Timing changes don't alter your dose, but they can affect when peak levels occur and how consistently the medication works for appetite control and metabolic benefits

It typically resolves within 3 to 7 days as the body adapts