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According to endocrinologists, the muscle loss during GLP-1 or semaglutide medication use is not unique to the drug its a consequence commonly seen in caloric restriction

Microglia are initially activated to stage 1 DAM, which are characterized by a downregulation of homeostatic microglial genes including p2ry12 and cx3cr1 , and an upregulation of genes including trem2 , tyrobp and apoe

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Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [2]