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According to NICE guideline NG28, GLP-1 receptor agonists should be considered when: Triple therapy (metformin and two other oral drugs) is not effective, not tolerated, or contraindicated The patient has a BMI 35 kg/m (or lower in people of Black, Asian and other minority ethnic groups) and specific obesity-related comorbidities The patient has a BMI 40% reduction in non-HDL cholesterol GLP-1 receptor agonist for glycaemic control and weight management (with secondary lipid benefits) Ezetimibe if non-HDL cholesterol reduction is insufficient Lifestyle interventions addressing diet, exercise, and weight Monitoring and follow-up are essential components of cholesterol management

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Peptides may not always show visible signs of degradation, yet their potency and behaviour can be compromised

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Moreover, semaglutide impacts hunger-related hormones by lowering the production of ghrelin, the hunger hormone, effectively reducing the sensation of hunger

For patients who dont respond well to GLP1 medications or dont achieve the weight loss theyre hoping for, other treatment paths exist