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Nat Commun 5:111 Brasil ADA, Carvalho MDCD, Gerhardt E et al (2019) Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

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The brainstem-cortex network plays a critical role in the migraine pathway, with conditions such as insomnia, obstructive sleep apnea, sleep-related movement disorders, and REM sleep disturbances closely associated with migraine onset ( 3.2 Pathophysiological mechanisms of migraine The pathophysiological mechanisms of migraine are complex, and multiple hypotheses exist