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One Reddit user, who later spoke with STAT News/Undark, described living with hypermobility spectrum disorder, a condition that at its worst made it impossible to even walk around the block. He wanted to strengthen the muscles around his joints, but was so injury-prone that workouts often left him feeling worse

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Glutamate, ornithine, arginine, proline, and polyamine metabolic interactions: the pathway is regulated at the post-transcriptional level

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The weight loss it produces, while clinically significant, comes almost entirely from reduced caloric intake rather than from metabolic changes that increase how many calories the body burns at rest