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When we understand the mechanism, we can better tailor the intervention

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Considering the potential of secondary bile acids to increase L-cells and GLP-1 secretion by TGR5, TGR5 agonists are promising drug candidates for increasing L-cells and GLP-1 secretion [180, 181]

Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice

The comprehensive safety profile supports its integration into existing pharmaceutical development pipelines with minimal regulatory complexities

Liu says