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For Ozempic (semaglutide for type 2 diabetes), headache rates were somewhat lower but still more frequent than placebo in the SUSTAIN clinical trial program
However, GLP-1 RAs are often preferred for T2D subjects with obesity or cardiovascular disease, providing a potential for confounding by indication
Based on this assumption, Ile 12 could be replaced with Leu or Val and retain the same effect
This article explores practical, clinically informed approaches to optimising your natural GLP-1 response
1 Be patient and continue working with your healthcare team
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