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Major cardiovascular outcomes trials such as SUSTAIN-6 and PIONEER-6 included patients with various comorbidities, but did not specifically report outcomes in autoimmune disease subgroups, representing a knowledge gap in this area
For autoimmune patients, this creates a challenging overlap where it becomes difficult to determine whether fatigue is disease-related, medication-related, or both
Changes in weight and body composition could also put extra strain on the back
Its a crucial distinction to makeits prohibition in athletics is about maintaining fair play, not necessarily about inherent danger in a lab context
Further controlled human studies are necessary to clarify safety parameters, long term outcomes, and any potential translational relevance within clinical research frameworks
Understanding when increased urination is normal versus when it signals a problem helps patients safely benefit from this effective medication while managing potential side effects appropriately
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