GLP-1 drugs, a class of obesity and diabetes medications that includes Ozempic, Wegovy, Zepbound, and Mounjaro, are known to produce significant weight loss
Over the past several years GLP-1 receptor agonists have been developed as medications for managing diabetes, cardiovascular disease, and obesity
10.1074/jbc.M113.512046 45 HabeggerK
PMID:27499338
An arginine substitution at position 34 removes an immunogenic risk present in native GLP-1
They framed the gutbrain axis as a dynamic bidirectional signaling network whose dysregulation underlies a broad spectrum of neurogastrointestinal diseases, positioning EVs as key mediators of intercellular communication and promising non-invasive biomarkers Derived from both host and microbial cells, EVs carry bioactive cargo, including proteins, lipids, nucleic acids, and metabolites, that reflects the physiological or pathological state of their origin and can traverse biological barriers such as the bloodbrain barrier