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Sparse whole-genome sequencing identifies two loci for major depressive disorder

Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K/Akt/eNOS signaling pathway in diabetic tubulopathy

One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors

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The incidence of PCD in The Faroe Islands is the highest recorded in the world (1:297) 9 and to our knowledge, we are the first to systematically investigate a population of PCD patients for myocardiac scarring and function using CMR