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Takeda Pharmaceutical is developing the Nimbus-discovered tyrosine kinase 2 (TYK2) inhibitor zasocitinib as a once-daily oral treatment for moderate-to-severe plaque psoriasis
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Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Christian D, Coppi A, Warner F, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Mouslmani M, Hooper W, Putrino D, Carr K, Charnas L, De Jesus M, Nepert D, Abreu P, Ziegler F, Spertus J, Iwasaki A, Krumholz H
These groundbreaking medications have gained attention for their impressive weight-loss results in clinical trials
At day 16, the livers were examined for steatosis, changes in hepatic expression of genes involved in de novo lipogenesis, oxidant stress and inflammation
The rash was characterized by dull pain, burning, and soreness that spread over 10 days
