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Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production
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The compound acts on the enzyme directly and does not engage central nervous system receptors
Light protection is the one genuine control, because substituted quinolinium compounds absorb visibly and aromatic amines are prone to photochemical and oxidative discolouration
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule that stops NNMT (Nicotinamide N-methyltransferase) from working
