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One randomized, single-blind, crossover study focused on the ability of fiber to increase GLP-1 secretion

Not only did primary analysis reveal reduced death from cardiovascular causes and non-fatal myocardial infarction overall, but prespecified secondary analysis also showed that, among patients with atherosclerotic disease and heart failure, there were reduced composite heart failure hospitalizations and cardiovascular deaths among patients taking semaglutide

Without a target, an observed effect is an observation, and describing it as a mechanism goes beyond what the experiment can carry

Understanding what GLP-1 is, along with rising GLP-1 demand, helps employers make informed coverage decisions

Sensitivity analyses included a mixed-effects model for repeated measures and exclusion of post-baseline data from non-adherent participants to confirm robustness

Together they function as a two-phase system: signal and scaffold first, migration and sustained remodelling second