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IGF-1 LR3 primarily exerts its effects through activation of the IGF-1 receptor (IGF-1R), a transmembrane tyrosine kinase receptor expressed in muscle, bone, connective tissue, and various other cell types

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Both male and female mice were housed under controlled conditions of 12 h:12 h light-dark cycles and at 22 C temperature and 4555% humidity and fed ad libitum a standard rodent chow diet (CHD) or high fat diet (HFD) (60% of calories from fat) for 12 (males) or 24 (females) weeks starting at week 8 of age

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