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Ethics declarations Competing Interests M.R.H

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A.KulkarniR

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The prevention and/or early treatment of accompanying physical comorbidities may, per s, may also modify the DE course

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37 RCTs Meta-Analysis (2020) Weight loss: -1.13 kg BMI: -0.36 points Fat mass: -1.16 kg Waist circumference: -1.24 cm Umbrella Meta-Analysis (2025) Confirms: statistically significant weight loss , especially combined with exercise

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Anatomical Changes Stomach pouches and sleeves can stretch over years of use

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Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 (736 amide) after subcutaneous injection in healthy volunteers

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